All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Acetylcholinesterase inhibitors and drugs acting on muscarinic receptors-potential crosstalk of cholinergic mechanisms during pharmacological treatment

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F17%3A43875754" target="_blank" >RIV/60162694:G44__/17:43875754 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/17:10361342 RIV/00179906:_____/17:10361342

  • Result on the web

    <a href="http://www.eurekaselect.com/143096/article" target="_blank" >http://www.eurekaselect.com/143096/article</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/1570159X14666160607212615" target="_blank" >10.2174/1570159X14666160607212615</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Acetylcholinesterase inhibitors and drugs acting on muscarinic receptors-potential crosstalk of cholinergic mechanisms during pharmacological treatment

  • Original language description

    Most pharmaceuticals targeting muscarinic receptors are employed at such large doses that no selectivity can be expected. However, some differences in the adverse effect profile of muscarinic antagonists may still be explained by the variation of expression of muscarinic receptor subtypes in different organs. However, a complex pattern of interactions between muscarinic receptor subtypes occurs and needs to be considered when searching for selective pharmaceuticals. In the development of new entities for the treatment of for instance pesticide intoxication, the muscarinic receptor selectivity needs to be considered. Reactivators generally have a muscarinic M2 receptor acting profile. Such a blockade may engrave the situation since it may enlarge the effect of the muscarinic M3 receptor effect. This may explain why respiratory arrest is the major cause for deaths by esterase blocking.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Neuropharmacology

  • ISSN

    1570-159X

  • e-ISSN

  • Volume of the periodical

    15

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    AE - UNITED ARAB EMIRATES

  • Number of pages

    17

  • Pages from-to

    637-653

  • UT code for WoS article

    000402461000012

  • EID of the result in the Scopus database

    2-s2.0-85010685416