Acetylcholinesterase inhibitors and drugs acting on muscarinic receptors-potential crosstalk of cholinergic mechanisms during pharmacological treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F17%3A43875754" target="_blank" >RIV/60162694:G44__/17:43875754 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/17:10361342 RIV/00179906:_____/17:10361342
Result on the web
<a href="http://www.eurekaselect.com/143096/article" target="_blank" >http://www.eurekaselect.com/143096/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1570159X14666160607212615" target="_blank" >10.2174/1570159X14666160607212615</a>
Alternative languages
Result language
angličtina
Original language name
Acetylcholinesterase inhibitors and drugs acting on muscarinic receptors-potential crosstalk of cholinergic mechanisms during pharmacological treatment
Original language description
Most pharmaceuticals targeting muscarinic receptors are employed at such large doses that no selectivity can be expected. However, some differences in the adverse effect profile of muscarinic antagonists may still be explained by the variation of expression of muscarinic receptor subtypes in different organs. However, a complex pattern of interactions between muscarinic receptor subtypes occurs and needs to be considered when searching for selective pharmaceuticals. In the development of new entities for the treatment of for instance pesticide intoxication, the muscarinic receptor selectivity needs to be considered. Reactivators generally have a muscarinic M2 receptor acting profile. Such a blockade may engrave the situation since it may enlarge the effect of the muscarinic M3 receptor effect. This may explain why respiratory arrest is the major cause for deaths by esterase blocking.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Neuropharmacology
ISSN
1570-159X
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
4
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
17
Pages from-to
637-653
UT code for WoS article
000402461000012
EID of the result in the Scopus database
2-s2.0-85010685416