Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F17%3A43889211" target="_blank" >RIV/60162694:G44__/17:43889211 - isvavai.cz</a>

Result on the web

<a href="http://onlinelibrary.wiley.com/wol1/doi/10.1111/cmi.12769/full" target="_blank" >http://onlinelibrary.wiley.com/wol1/doi/10.1111/cmi.12769/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cmi.12769" target="_blank" >10.1111/cmi.12769</a>

Result language

angličtina

Original language name

Subversion of innate immune responses by Francisella involves the disruption of TRAF3 and TRAF6 signalling complexes

Original language description

The success of pathogens depends on their ability to circumvent immune defences. Francisella tularensis is one of the most infectious bacteria known. The remarkable virulence of Francisella is believed to be due to its capacity to evade or subvert the immune system, but how remains obscure. Here, we show that Francisella triggers but concomitantly inhibits the Toll-like receptor, RIG-I-like receptor, and cytoplasmic DNA pathways. Francisella subverts these pathways at least in part by inhibiting K63-linked polyubiquitination and assembly of TRAF6 and TRAF3 complexes that control the transcriptional responses of pattern recognition receptors. We show that this mode of inhibition requires a functional type VI secretion system and/or the presence of live bacteria in the cytoplasm. The ability of Francisella to enter the cytosol while simultaneously inhibiting multiple pattern recognition receptor pathways may account for the notable capacity of this bacterium to invade and proliferate in the host without evoking a self-limiting innate immune response.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cellular Microbiology

ISSN

1462-5814

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000412834200008

EID of the result in the Scopus database

2-s2.0-85031042230