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Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F17%3A43889223" target="_blank" >RIV/60162694:G44__/17:43889223 - isvavai.cz</a>

  • Alternative codes found

    RIV/62690094:18470/17:50013417 RIV/00179906:_____/17:10362184 RIV/61988987:17110/17:A1901ZGZ

  • Result on the web

    <a href="http://www.tandfonline.com/doi/full/10.1080/13543776.2017.1338275" target="_blank" >http://www.tandfonline.com/doi/full/10.1080/13543776.2017.1338275</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/13543776.2017.1338275" target="_blank" >10.1080/13543776.2017.1338275</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)

  • Original language description

    Introduction: organophosphorus compounds act as irreversible inhibitors of the vital enzyme acetylcholinesterase (AChE). this leads in the accumulation of acetylcholine (ACh) leading to cholinergic crisis and death. The main therapeutic approach is based on immediate administration of an ache reactivator as an antidote enabling recovery of the ache function. Areas covered: This review covers the development of AChE reactivators in order to introduce a new efficient drug that will overcome significant failures of common antidotes. Further options together with methods of detection are also discussed in order to assure a complete insight into the treatment of intoxication. Expert opinion: Since organophosphates belong to the most toxic chemical warfare agents, efficient antidotes are a matter of importance. The solution of how to limit the basic drawbacks of clinically used reactivators remained a spotlight for many researches worldwide. Recent strategies of the treatment of OP exposure bring us new possibilities which may overcome classic antidotes. The importance of detection of OP also has to be taken into consideration. Especially, with the fast spreading toxic effect when death can occur within minutes.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Expert Opinion on Therapeutic Patents

  • ISSN

    1354-3776

  • e-ISSN

  • Volume of the periodical

    27

  • Issue of the periodical within the volume

    9

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    15

  • Pages from-to

    971-985

  • UT code for WoS article

    000407436800001

  • EID of the result in the Scopus database

    2-s2.0-85028186082