Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F17%3A43889386" target="_blank" >RIV/60162694:G44__/17:43889386 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/17:50013673 RIV/00179906:_____/17:10364046
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0141813016328197?via%3Dihub" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0141813016328197?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijbiomac.2017.06.006" target="_blank" >10.1016/j.ijbiomac.2017.06.006</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids
Original language description
A novel series of acridine-coumarin hybrids was synthesized and biologically evaluated for their potential inhibitory effect on both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The newly synthesized derivatives 9a-d have shown higher activity against human AChE (hAChE) compared with 7-MEOTA as the standard drug. Among them derivative 9b exhibited the most potent acetylcholinesterase inhibitory activity, with an IC50 value of 5.85 mu M compared with 7-MEOTA (IC50 = 15 mu M). Molecular modelling studies were performed to predict the binding modes of compounds 9b, 9c and 9f with hAChE/hBuChE. (C) 2017 Published by Elsevier B.V.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/NV15-30954A" target="_blank" >NV15-30954A: Development of multi-target drugs for Alzheimer´s disease: combination of AChE inhibitor and melatonin derivative</a><br>
Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Biological Macromolecules
ISSN
0141-8130
e-ISSN
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Volume of the periodical
104
Issue of the periodical within the volume
Part A
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
6
Pages from-to
333-338
UT code for WoS article
000412959300037
EID of the result in the Scopus database
2-s2.0-85020659867