Evaluation of the influence of three newly developed bispyridinium anti-nicotinic compounds (MB408, MB442, MB444) on the efficacy of antidotal treatment of nerve agent poisoning in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889469" target="_blank" >RIV/60162694:G44__/18:43889469 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/bcpt.12935" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1111/bcpt.12935</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bcpt.12935" target="_blank" >10.1111/bcpt.12935</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of the influence of three newly developed bispyridinium anti-nicotinic compounds (MB408, MB442, MB444) on the efficacy of antidotal treatment of nerve agent poisoning in mice
Original language description
The influence of three newly developed bispyridinium antinicotinic compounds (the non-oximes MB408, MB442 and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with an oxime) of acute poisoning by the organophosphorus nerve agents tabun and soman was studied in mice. The therapeutic efficacy of atropine in combination with an oxime with or without one of the bispyridinium non-oximes was evaluated by determination of the LD50 values of the nerve agents and measurement of the survival time after supralethal poisoning. Addition of all the tested non-oximes increased significantly the therapeutic efficacy of atropine in combination with an oxime against tabun poisoning. They also positively influenced the number of surviving mice 6 hr after supralethal poisoning with tabun. However, they were only slightly effective for the treatment of soman poisoning. The benefit of the tested bispyridinium non-oximes was dose-dependent. To conclude, the addition of bispyridinium non-oximes to the standard antidotal treatment of acute poisoning with tabun was beneficial regardless of the chosen non-oxime, but only slightly beneficial in the case of soman poisoning.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Basic and Clinical Pharmacology and Toxicology
ISSN
1742-7835
e-ISSN
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Volume of the periodical
122
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
429-435
UT code for WoS article
000427113100009
EID of the result in the Scopus database
2-s2.0-85037373285