New light on an old friend: targeting PUMA in radioprotection and therapy of cardiovascular and neurodegenerative diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F18%3A43889712" target="_blank" >RIV/60162694:G44__/18:43889712 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/18:10385041 RIV/00216208:11150/18:10385041

Result on the web

<a href="http://www.eurekaselect.com/161074/article" target="_blank" >http://www.eurekaselect.com/161074/article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1389450119666180406110743" target="_blank" >10.2174/1389450119666180406110743</a>

Result language

angličtina

Original language name

New light on an old friend: targeting PUMA in radioprotection and therapy of cardiovascular and neurodegenerative diseases

Original language description

This review summarizes recent progress in understanding the role of p53-upregulated mediator of apoptosis (PUMA) in molecular pathways with respect to its potential therapeutic applications. Particular emphasis is given to the PUMA&apos;s role in ionizing radiation-induced signalling as radiotoxicity of normal tissue is mediated mostly via apoptosis. PUMA and its p53-dependent and p53- independent induction are described and potential use as a new target for the development of radioprotective agents is suggested. Further implications, including targeting PUMA to prevent and treat cardiovascular and neurodegenerative diseases, are also discussed together with an overview of other therapeutic applications. Finally, basic chemical structures for the development of novel PUMA modulators such as pifithrine derivatives, kinase inhibitors or modulators of Bcl-2 protein family are described

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/GA17-13541S" target="_blank" >GA17-13541S: Development of novel radioprotective agents based on small molecule inhibitors</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Drug Targets

ISSN

1389-4501

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

16

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

15

Pages from-to

1943-1957

UT code for WoS article

000449269200007

EID of the result in the Scopus database

2-s2.0-85052623700