The role of alpha beta T-cells in spontaneous regression of melanoma tumors in swine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00536529" target="_blank" >RIV/60162694:G44__/19:00536529 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/19:00503686 RIV/67985904:_____/19:00503686 RIV/60460709:41210/19:78673 RIV/00064211:_____/19:W0002028
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0145305X18303884?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0145305X18303884?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dci.2018.10.001" target="_blank" >10.1016/j.dci.2018.10.001</a>

Result language
angličtina
Original language name
The role of alpha beta T-cells in spontaneous regression of melanoma tumors in swine
Original language description
Using a porcine model, we describe Melanoma-Associated CD4(+)CD8(hi) T-lymphocytes (MATL) in peripheral blood that increase during melanoma regression. These MATL possess the CD4(+)CD8(hi) phenotype and they have their direct counterparts in Tumor Infiltrating Lymphocytes (TIL) isolated from melanoma loci. Both MATL and CD4(+)CD8(hi) TIL have a similar expression of selected markers indicating that they rep(re)sent effector/memory alpha beta T-cell subset. Moreover, although TIL also contain CD4(-)CD8(hi) T-cells, only CD4(+)CD8(hi) TIL expand during melanoma regression. Importantly, TIL isolated from different pigs and different melanoma loci among the same pig have similar composition of CD4/CD8 subsets, indicating that the composition of the MATL and TIL compartment is identical. Analysis of sorted cells from regressing pigs revealed a unique MATL subpopulation with mono-specific T-cell receptor that was further analyzed by sequencing. These results indicate that pigs regressing melanomas possess a characteristic population of recirculating T-cells playing a role in tumor control and regression.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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