Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00537099" target="_blank" >RIV/60162694:G44__/19:00537099 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/19:10400121 RIV/00216275:25310/19:39915524 RIV/00179906:_____/19:10400121
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0031942219301979?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0031942219301979?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.phytochem.2019.112055" target="_blank" >10.1016/j.phytochem.2019.112055</a>
Alternative languages
Result language
angličtina
Original language name
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
Original language description
Twenty-one known Amaryllidaceae alkaloids of various structural types and one undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of Narcissus pseudonarcissus L. cv. Dutch Master. The chemical structures were elucidated by combination of MS, HRMS, 1D and 2D NMR spectroscopic techniques, and by comparison with literature data. Narcimatuline amalgamates two basic scaffolds of Amaryllidaceae alkaloids in its core, namely galanthamine and galanthindole. All isolated compounds were evaluated for their in vitro acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), prolyl oligopeptidase (POP), and glycogen synthase kinase-3 beta (GSK-3 beta) inhibitory activities. The most interesting biological profile was demonstrated by newly isolated alkaloid narcimatuline.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/EF16_019%2F0000841" target="_blank" >EF16_019/0000841: Efficiency and safety improvement of current drugs and nutraceuticals: advanced methods - new challenges</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Phytochemistry
ISSN
0031-9422
e-ISSN
0031-9422
Volume of the periodical
165
Issue of the periodical within the volume
Sep
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
112055
UT code for WoS article
000482248900010
EID of the result in the Scopus database
2-s2.0-85067977699