Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00537472" target="_blank" >RIV/60162694:G44__/19:00537472 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/19:50016115 RIV/00179906:_____/19:10402691
Result on the web
<a href="http://www.eurekaselect.com/170311/article" target="_blank" >http://www.eurekaselect.com/170311/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1567205016666190228122956" target="_blank" >10.2174/1567205016666190228122956</a>
Alternative languages
Result language
angličtina
Original language name
Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease
Original language description
Alzheimer's Disease (AD) is a neurodegenerative disorder with an increasing impact on society. Because currently available therapy has only a short-term effect, a huge number of novel compounds are developed every year exploiting knowledge of the various aspects of AD pathophysiology. To better address the pathological complexity of AD, one of the most extensively pursued strategies by medicinal chemists is based on Multi-target-directed Ligands (MTDLs). Donepezil is one of the currently approved drugs for AD therapy acting as an acetylcholinesterase inhibitor. In this review, we have made an extensive literature survey focusing on donepezil-derived MTDL hybrids primarily targeting on different levels cholinesterases and amyloid beta (A beta) peptide. The targeting includes direct interaction of the compounds with A beta, AChE-induced A beta aggregation, inhibition of BACE-1 enzyme, and modulation of biometal balance thus impeding A beta assembly.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
<a href="/en/project/NV15-30954A" target="_blank" >NV15-30954A: Development of multi-target drugs for Alzheimer´s disease: combination of AChE inhibitor and melatonin derivative</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Alzheimer Research
ISSN
1567-2050
e-ISSN
1875-5828
Volume of the periodical
16
Issue of the periodical within the volume
9
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
29
Pages from-to
772-800
UT code for WoS article
000493721100002
EID of the result in the Scopus database
2-s2.0-85072308142