Visual evoked and event-related brain potentials in HIV-infected adults: a longitudinal study over 2.5 years

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F19%3A00537490" target="_blank" >RIV/60162694:G44__/19:00537490 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/19:10406001 RIV/00179906:_____/19:10406001

Result on the web

<a href="https://link.springer.com/article/10.1007/s10633-019-09697-4" target="_blank" >https://link.springer.com/article/10.1007/s10633-019-09697-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10633-019-09697-4" target="_blank" >10.1007/s10633-019-09697-4</a>

Result language

angličtina

Original language name

Visual evoked and event-related brain potentials in HIV-infected adults: a longitudinal study over 2.5 years

Original language description

Purpose The aim of this neurophysiological study was to monitor changes in the visual and cognitive function of HIV-infected patients treated with combination antiretroviral therapy. Methods Eleven adult Czech HIV+ patients, with a mean age of 35 years and CD4 cell count >= 230 x 10(6) cells/L of blood at the time of enrollment, underwent four to six examinations over the course of 2.5 years to evaluate pattern-reversal and motion-onset visual evoked potentials (P-VEPs and M-VEPs), visually driven oddball event-related potentials (ERPs) and Montreal Cognitive Assessments. In addition to evaluating the intraindividual change in the observed parameters, we also compared patient data to data from eleven age- and gender-matched controls. Results We did not find any significant differences in P-VEPs between the patients and controls or in the paired comparison of the first and last visit. The only significant finding for P-VEPs was a linear trend in prolongation of the 20 ' P-VEP P100 peak time. In M-VEPs, we found a significant intergroup difference in the N160 peak time recorded during the first visit for peripheral M-VEPs only. During the last visit, all N160 peak times for patients differed significantly from those of the control group. The only intervisit difference close to the level of significance was for peripheral M-VEPs, which confirmed the trend analysis. No significant differences between patients and controls were found in the ERPs, but the P300 peak time showed a significant difference between the first and last visits, as confirmed by the trend. Patient reaction time was not significantly delayed at the first visit; however, it was prolonged with time, as confirmed by the trend. Conclusion Our aim was to evaluate whether antiretroviral treatment in HIV+ patients is sufficient to preserve brain visual function. The optic nerve and primary visual cortex function tested by the P-VEPs seem to be preserved. The prolongation of the M-VEPs suggests an individually detectable decline in CNS function, but these changes did not show a progression during the follow-up. From a longitudinal perspective, the trends in peak time prolongation of the 20 ' P-VEP, peripheral M-VEP, ERP and reaction time suggest a faster decline than that caused by aging in healthy populations, as previously described in a cross-sectional study.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30207 - Ophthalmology

Project

—

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Documenta Ophthalmologica

ISSN

0012-4486

e-ISSN

1573-2622

Volume of the periodical

139

Issue of the periodical within the volume

2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

15

Pages from-to

83-97

UT code for WoS article

000485306000001

EID of the result in the Scopus database

2-s2.0-85064712394