Searching for New Antimicrobial Agents by Targeting Bacterial NAD Metabolism: Evaluation of Frentizole Derivatives Selected by Molecular Docking

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F20%3A00555751" target="_blank" >RIV/60162694:G44__/20:00555751 - isvavai.cz</a>

Alternative codes found

RIV/62690094:18470/20:50016894 RIV/00179906:_____/20:10411778

Result on the web

<a href="https://www.mmsl.cz/artkey/mms-202002-0002_searching-for-new-antimicrobial-agents-by-targeting-bacterial-nad-metabolism-evaluation-of-frentizole-derivati.php" target="_blank" >https://www.mmsl.cz/artkey/mms-202002-0002_searching-for-new-antimicrobial-agents-by-targeting-bacterial-nad-metabolism-evaluation-of-frentizole-derivati.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.31482/mmsl.2020.005" target="_blank" >10.31482/mmsl.2020.005</a>

Result language

angličtina

Original language name

Searching for New Antimicrobial Agents by Targeting Bacterial NAD Metabolism: Evaluation of Frentizole Derivatives Selected by Molecular Docking

Original language description

Growing evidence of antibiotic-resistant pathogens is a serious medical issue that has to be addressed. Our antimicrobial research is focused on searching for novel small molecules that differ from the most clinically used antibiotics by chemical structure and mechanism. However, this fundamental research is like looking for a needle in a haystack. In addition, in vitro methods are time-consuming and expensive to screen large number of compounds in reasonable time. Off-target screening can represent a solution to find novel and effective antimicrobial agents that can eliminate these problems. Accordingly, molecular docking in the family of selected frentizole derivatives predicted their potential to inhibit bacterial nicotinate mononucleotide adenylyltransferase (NadD). This bacterial-essential specific enzyme has an important role in NAD metabolism. Thus, underlying mechanism of antimicrobials derived from frentizole would be interference with this biochemical process. Unfortunately, broth microdilution assay did not display any antimicrobial activity of tested compounds. On the other hand, herein we propose that off-target screening can facilitate searching for new drugs and that NadD could be a relevant target for antimicrobials.

Czech name

—

Czech description

—

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

30107 - Medicinal chemistry

Project

<a href="/en/project/NV18-09-00181" target="_blank" >NV18-09-00181: Development of polyvalent decontamination mean</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Military Medical Science Letters

ISSN

0372-7025

e-ISSN

2571-113X

Volume of the periodical

89

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

66-73

UT code for WoS article

—

EID of the result in the Scopus database

2-s2.0-85086029676