The Antibacterial Effects of New N-Alkylpyridinium Salts on Planktonic and Biofilm Bacteria
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F20%3A00556173" target="_blank" >RIV/60162694:G44__/20:00556173 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/20:10418099
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fmicb.2020.573951/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Microbiology&id=573951" target="_blank" >https://www.frontiersin.org/articles/10.3389/fmicb.2020.573951/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Microbiology&id=573951</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fmicb.2020.573951" target="_blank" >10.3389/fmicb.2020.573951</a>
Alternative languages
Result language
angličtina
Original language name
The Antibacterial Effects of New N-Alkylpyridinium Salts on Planktonic and Biofilm Bacteria
Original language description
An increasing microbial resistance to known antibiotics raises a demand for new antimicrobials. In this study the antimicrobial properties of a series of new N-Alkylpyridinium quaternary ammonium compounds (QACs) with varying alkyl chain lengths were evaluated for several nosocomial pathogens. The chemical identities of the new QACs were determined by NMR, LC-MS, and HRMS. All the planktonic bacteria tested were susceptible to the new QACs as evaluated by MIC and MBC assays. The antimicrobial effect was most pronounced against Staphylococcus aureus clinical isolates. Live/dead staining CLSM was used to test the effectiveness of the QACs in biofilms. The effectiveness was up to 10-fold lower than in the plankton. When QACs were used as irrigants in Er:YAG - SSP photoacoustic steaming, their effectiveness significantly increased. The combined use of irrigants and photoacoustic streaming increased biofilm removal from the surface and increased the killing rate of the cells remaining on the surface. This may allow for a shorter chemical exposure time and lower dosage of QACs used in applications. The results demonstrate that the new QACs have potential to be applied as antibacterial compounds effective against planktonic and biofilm bacteria as well as irrigants in removal of difficult-to-reach biofilms.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
<a href="/en/project/NV19-09-00198" target="_blank" >NV19-09-00198: Development of novel quaternary ammonium compounds against microbial biofilm in oral cavity</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Microbiology
ISSN
1664-302X
e-ISSN
—
Volume of the periodical
11
Issue of the periodical within the volume
Oct
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
573951
UT code for WoS article
000583827100001
EID of the result in the Scopus database
2-s2.0-85094939852