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Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F24%3A00560327" target="_blank" >RIV/60162694:G44__/24:00560327 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.tandfonline.com/eprint/VUSYS6EPGUGGJYAQVUCQ/full?target=10.1080/15376516.2023.2202730" target="_blank" >https://www.tandfonline.com/eprint/VUSYS6EPGUGGJYAQVUCQ/full?target=10.1080/15376516.2023.2202730</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1080/15376516.2023.2202730" target="_blank" >10.1080/15376516.2023.2202730</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Combination of acetylcholinesterase inhibitors and NMDA receptor antagonists increases survival rate in soman-poisoned mice

  • Original language description

    Organophosphorus nerve agents pose a global threat to both military personnel and civilian population, because of their high acute toxicity and insufficient medical countermeasures. Commonly used drugs could ameliorate the intoxication and overall medical outcomes. In this study, we tested the drugs able to alleviate the symptoms of Alzheimer’s disease (donepezil, huperzine A, memantine) or Parkinson’s disease (procyclidine). They were administered to mice before soman intoxication in terms of their: i) protection potential against soman toxicity and ii) influence on post-exposure therapy consisting of atropine and asoxime (also known as oxime HI-6). Their pretreatment effect was not significant, when administered alone, but in combination (acetylcholinesterase inhibitor such as donepezil or huperzine A with NMDA antagonist such as memantine or procyclidine) they lowered the soman toxicity more than twice. These combinations also positively influenced the efficacy of post-exposure treatment in a similar fashion; the combinations increased the therapeutic effectiveness of antidotal treatment. In conclusion, the most effective combination – huperzine A and procyclidine – lowered the toxicity three times and improved the post-exposure therapy efficacy more than six times. These results are unprecedented in the published literature.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30108 - Toxicology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Toxicology Mechanisms and Methods

  • ISSN

    1537-6516

  • e-ISSN

    1537-6524

  • Volume of the periodical

    33

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    590-595

  • UT code for WoS article

    000971422200001

  • EID of the result in the Scopus database

    2-s2.0-85153509010