Genetic relationship between placental and fetal weights and markers of the metabolic syndrome in rat recombinant inbred strains

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F06%3A16333" target="_blank" >RIV/60460709:41210/06:16333 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/06:00040557 RIV/00216208:11110/06:00004940 RIV/00064165:_____/06:00000566 RIV/00023001:_____/06:00001385

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Genetic relationship between placental and fetal weights and markers of the metabolic syndrome in rat recombinant inbred strains

Original language description

Epidemiological studies have shown a clear link between fetal growth retardation and an increased propensity for later cardiovascular disease in adults. It has been hypothesized that such early fetal deprivation "programs" individuals toward a life-longmetabolical "thrifty phenotype" that predisposes adults to such diseases. Here we test this hypothesis, and its possible genetic basis, in rat recombinant inbred (RI) strains that uniquely allow the longitudinal studies necessary for its testing. Placental and fetal weights were determined on day 20 of pregnancy in (at least) 6 litters from each of 25 available BXH/HXB RI strains and from their SHR and BN-Lx progenitors and were correlated with metabolic traits determined in adult rats from the same inbred lines. Quantitative trait loci (QTLs) associated with placental and fetal weights were identified by total genome scanning of RI strains using the Map Manager QTX program. Heritabilities of placental and fetal weights were 56% and 62%

Czech name

Genetická závislost mezi hmotností placenty a plodu a markery metabolického syndromu u rekombinantních inbredních kmenů potkana

Czech description

Epidemiological studies have shown a clear link between fetal growth retardation and an increased propensity for later cardiovascular disease in adults. It has been hypothesized that such early fetal deprivation "programs" individuals toward a life-longmetabolical "thrifty phenotype" that predisposes adults to such diseases. Here we test this hypothesis, and its possible genetic basis, in rat recombinant inbred (RI) strains that uniquely allow the longitudinal studies necessary for its testing. Placental and fetal weights were determined on day 20 of pregnancy in (at least) 6 litters from each of 25 available BXH/HXB RI strains and from their SHR and BN-Lx progenitors and were correlated with metabolic traits determined in adult rats from the same inbred lines. Quantitative trait loci (QTLs) associated with placental and fetal weights were identified by total genome scanning of RI strains using the Map Manager QTX program. Heritabilities of placental and fetal weights were 56% and 62%

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GG - Zootechnics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Genomics

ISSN

1094-8341

e-ISSN

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Volume of the periodical

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Issue of the periodical within the volume

26

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

226-231

UT code for WoS article

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EID of the result in the Scopus database

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