Correlation between antibodies and histology in celiac disease: Incidence of celiac disease is higher than expected in the pediatric population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F13%3A60537" target="_blank" >RIV/60460709:41210/13:60537 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/13:00396298

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Correlation between antibodies and histology in celiac disease: Incidence of celiac disease is higher than expected in the pediatric population

Original language description

The present study aims to report on the correlation between the degree of negativity of anti-endomysial antibodies and anti-tissue transglutaminase antibodies in the IgA and IgG classes with regard to histological grade, in 44 newly diagnosed children with celiac disease (CD). Samples with negative antibodies, but a positive histology from a 5-year program searching for CD in the pediatric population were collected. A total of 4247 biopsy samples were used in this study. We documented that certain pediatric patients are seronegative, while the disease is active and the incidence of CD is higher than expected in the pediatric population. This is an important finding, which demonstrates the lack of association between autoantibodies and lesions, and justifies the use of biopsies for an accurate CD diagnosis and the importance of revising the diagnostic criteria in a clinical, endoscopic and serological context. We recommend a more active search for incidences of the disease in the pediat

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FG - Paediatrics

OECD FORD branch

—

Project

<a href="/en/project/NT13424" target="_blank" >NT13424: MiR137 and its influence on the production of mucin as a potential tool in early diagnosis of colorectal cancer or colorectal cancer relapse</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Medicine Reports

ISSN

1791-2997

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

1079-1083

UT code for WoS article

000324815400020

EID of the result in the Scopus database

—