In vitro antistaphylococcal synergistic effect of isoflavone metabolite demethyltexasin with amoxicillin and oxacillin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A74459" target="_blank" >RIV/60460709:41210/18:74459 - isvavai.cz</a>

Alternative codes found

RIV/60460709:41340/18:74459

Result on the web

<a href="http://dx.doi.org/10.1089/mdr.2017.0033" target="_blank" >http://dx.doi.org/10.1089/mdr.2017.0033</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1089/mdr.2017.0033" target="_blank" >10.1089/mdr.2017.0033</a>

Result language

angličtina

Original language name

In vitro antistaphylococcal synergistic effect of isoflavone metabolite demethyltexasin with amoxicillin and oxacillin

Original language description

Staphylococcal infections are often hard to treat due to increasing resistance, especially to beta-lactams. Previous studies described the synergy between common antibiotics and isoflavonoids. However, little is yet known about the combinatory effects of antibiotics with products of human isoflavone metabolism. In this study, demethyltexasin (DT), a human body metabolite of soybean isoflavones, was evaluated for its possible antistaphylococcal combinatory effect with amoxicillin and oxacillin. For comparison, common therapeutically used combination of amoxicillin/clavulanic acid was tested. DT showed strong synergistic interactions against most of Staphylococcus aureus strains when combined with amoxicillin and oxacillin. When oxacillin was combined with DT, resistance to this antibiotic was overcome in many cases. Moreover, antibiotic/DT combinations were effective mainly against methicillin-resistant S. aureus (MRSA). However, the commonly used drug amoxicillin/clavulanic acid was effective only ag

Czech name

—

Czech description

—

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

—

OECD FORD branch

21101 - Food and beverages

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Microbial Drug Resistance

ISSN

1076-6294

e-ISSN

1931-8448

Volume of the periodical

24

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

24-29

UT code for WoS article

000419819100004

EID of the result in the Scopus database

2-s2.0-85040612785