Silymarin prevents acetaminophen-induced hepatotoxicity in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A76318" target="_blank" >RIV/60460709:41210/18:76318 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/18:00076540 RIV/61989592:15110/18:73584837
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0191353" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0191353</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0191353" target="_blank" >10.1371/journal.pone.0191353</a>
Alternative languages
Result language
angličtina
Original language name
Silymarin prevents acetaminophen-induced hepatotoxicity in mice
Original language description
Acetaminophen or paracetamol (APAP) overdose is a common cause of liver injury. Silymarin (SLM) is a hepatoprotective agent widely used for treating liver injury of different origin. In order to evaluate the possible beneficial effects of SLM, Balb/c mice were pretreated with SLM (100 mg/kg b.wt. per os) once daily for three days. Two hours after the last SLM dose, the mice were administered APAP (300 mg/kg b.wt. i.p.) and killed 6 (T6), 12 (T12) and 24 (T24) hours later. SLM-treated mice exhibited a significant reduction in APAP-induced liver injury, assessed according to AST and ALT release and histological examination. SLM treatment significantly reduced superoxide production, as indicated by lower GSSG content, lower HO-1 induction, alleviated nitrosative stress, decreased p-JNK activation and direct measurement of mitochondrial superoxide production in vitro. SLM did not affect the APAP-induced decrease in CYP2E1 activity and expression during the first 12 hrs. Neutrophil infiltration and enh
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/GA17-08888S" target="_blank" >GA17-08888S: Effect of silymarin combined with hypolipidemics on mechanisms leading to lipids accumulation, oxidative stress and inflammation in metabolic syndrome</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS One
ISSN
1932-6203
e-ISSN
1932-6203
Volume of the periodical
13
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
1-20
UT code for WoS article
000422653800066
EID of the result in the Scopus database
2-s2.0-85040712178