Anti-infectivity against herpes simplex virus and selected microbes and anti-inflammatory activities of compounds isolated from Eucalyptus globulus Labill.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F18%3A76671" target="_blank" >RIV/60460709:41210/18:76671 - isvavai.cz</a>
Alternative codes found
RIV/60460709:41330/18:76671 RIV/62157124:16370/18:43876555
Result on the web
<a href="http://dx.doi.org/10.3390/v10070360" target="_blank" >http://dx.doi.org/10.3390/v10070360</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/v10070360" target="_blank" >10.3390/v10070360</a>
Alternative languages
Result language
angličtina
Original language name
Anti-infectivity against herpes simplex virus and selected microbes and anti-inflammatory activities of compounds isolated from Eucalyptus globulus Labill.
Original language description
Herpes simplex virus (HSV) causes numerous mild-to-serious human diseases, including mucocutaneous herpes infections and life-threatening herpes encephalitis. Moreover, herpes viral lesions can be complicated by inflammation and secondary bacterial infections. The development of resistance to antiviral drugs along with the undesirable side effects of these drugs are relevant argue for the development of new anti-HSV drugs with diverse mechanisms of action. Eucalyptus extracts have been used for decades to combat various infectious diseases. We isolated and studied 12 pure compounds and one mixture of two constitutional isomers from the leaves and twigs of E. globulus. The structures were identified by spectroscopic methods (NMR, HR-MS, IR) and all of them were tested for antiherpetic activity against the replication of antigen types HSV-1 and HSV-2. Tereticornate A (12) (IC50 0,96 mcg per mL, selectivity index CC50 to IC50 was 218,8) showed the strongest activity in the anti-HSV-1 assay, even greater
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GA16-07193S" target="_blank" >GA16-07193S: Anti-inflammatory activity of selected stilbenoids, 2-arylbenzofuranes and their metabolites</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Viruses-Basel
ISSN
1999-4915
e-ISSN
1999-4915
Volume of the periodical
10
Issue of the periodical within the volume
7
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
18
Pages from-to
360-377
UT code for WoS article
000445153200022
EID of the result in the Scopus database
2-s2.0-85049837464