Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F19%3A80797" target="_blank" >RIV/60460709:41210/19:80797 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/19:43878255
Result on the web
<a href="https://www.mdpi.com/2218-273X/9/9/468/htm" target="_blank" >https://www.mdpi.com/2218-273X/9/9/468/htm</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biom9090468" target="_blank" >10.3390/biom9090468</a>
Alternative languages
Result language
angličtina
Original language name
Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System
Original language description
The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have investigated a group of 19 stilbenoid substances in vitro using a cellular model of THP-1 macrophage-like cells and pyocyanin-induced oxidative stress to evaluate their antioxidant or pro-oxidant properties. Then we have determined any effects that they might have on the expression of the enzymes catalase, glutathione peroxidase, and heme oxygenase-1, and their effects on the activation of Nrf2. The experimental results showed that these stilbenoids could affect the formation of reactive oxygen species in a cellular model, producing either an antioxidative or pro-oxidative effect, depending on the structure pinostilbene (2) worked as a pro-oxidant and also decreased expression of catalase in the cell culture.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA16-07193S" target="_blank" >GA16-07193S: Anti-inflammatory activity of selected stilbenoids, 2-arylbenzofuranes and their metabolites</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomolecules
ISSN
2218-273X
e-ISSN
2218-273X
Volume of the periodical
9
Issue of the periodical within the volume
9
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
1-16
UT code for WoS article
000489102800080
EID of the result in the Scopus database
2-s2.0-85072034634