Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-kB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F19%3A80839" target="_blank" >RIV/60460709:41210/19:80839 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b00081" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jnatprod.9b00081</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jnatprod.9b00081" target="_blank" >10.1021/acs.jnatprod.9b00081</a>
Alternative languages
Result language
angličtina
Original language name
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-kB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase
Original language description
Stilbenoids are important components of foods (e.g., peanuts, grapes, various edible berries), beverages (wine, white tea), and medicinal plants. Many publications have described the anti-inflammatory potential of stilbenoids, including the widely known trans-resveratrol and its analogues. However, comparatively little information is available regarding the activity of their prenylated derivatives. One new prenylated stilbenoid was isolated from Artocarpus altilis and characterized structurally based on 1D and 2D NMR analysis and HRMS. Three other prenylated stilbenoids were prepared synthetically. The ability of prenylated stilbenoids to attenuate the production of pro-inflammatory cytokines tumor necrosis factor-alfa (TNF-alfa) and interleukin-1beta (IL-1beta) was further evaluated using LPS-stimulated THP-1 macrophages.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30308 - Nutrition, Dietetics
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Natural Products
ISSN
0163-3864
e-ISSN
1520-6025
Volume of the periodical
82
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
1839-1848
UT code for WoS article
000477917800013
EID of the result in the Scopus database
2-s2.0-85070545805