Can oocytes repair fragmented DNA of spermatozoa?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F20%3A84373" target="_blank" >RIV/60460709:41210/20:84373 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/20:00073194 RIV/00216224:14110/20:00116518

Result on the web

<a href="https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml" target="_blank" >https://content.sciendo.com/configurable/contentpage/journals$002facb$002f8$002f2$002farticle-p73.xml</a>

DOI - Digital Object Identifier

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Result language

čeština

Original language name

Can oocytes repair fragmented DNA of spermatozoa?

Original language description

Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes.

Czech name

Can oocytes repair fragmented DNA of spermatozoa?

Czech description

Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes.

Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

10604 - Reproductive biology (medical aspects to be 3)

Project

<a href="/en/project/LTC18059" target="_blank" >LTC18059: Cultivation system suitable for long-term cultivation of human follicular cells</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medical Journal of Cell Biology

ISSN

2544-3577

e-ISSN

2544-3577

Volume of the periodical

8

Issue of the periodical within the volume

2

Country of publishing house

PL - POLAND

Number of pages

5

Pages from-to

73-77

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-85093648007