New perspective on the geographic distribution and evolution of Lymphocytic Choriominingitis, Central Europe
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F21%3A88293" target="_blank" >RIV/60460709:41210/21:88293 - isvavai.cz</a>
Result on the web
<a href="https://wwwnc.cdc.gov/eid/article/27/10/21-0224_article" target="_blank" >https://wwwnc.cdc.gov/eid/article/27/10/21-0224_article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3201/eid2710.210224" target="_blank" >10.3201/eid2710.210224</a>
Alternative languages
Result language
angličtina
Original language name
New perspective on the geographic distribution and evolution of Lymphocytic Choriominingitis, Central Europe
Original language description
Lymphocytic choriomeningitis virus (LCMV) is an Old World mammarenavirus found worldwide because of its association with the house mouse. When LCMV spills over to immunocompetent humans, the virus can cause aseptic meningitis, in immunocompromised persons, systemic infection and death can occur. Central Europe is a strategic location for the study of LCMV evolutionary history and host specificity because of the presence of a hybrid zone (genetic barrier) between 2 house mouse subspecies, Mus musculus musculus and M. musculus domesticus. We report LCMV prevalence in natural mouse populations from a Czech Republic-Germany transect and genomic characterization of 2 new LCMV variants from the Czech Republic. We demonstrate that the main division in the LCMV phylogenetic tree corresponds to mouse host subspecies and, when the virus is found in human hosts, the mouse subspecies found at the spillover location. Therefore, LCMV strains infecting humans can be predicted by the genetic structure of house mice.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EMERGING INFECTIOUS DISEASES
ISSN
1080-6040
e-ISSN
1080-6059
Volume of the periodical
27
Issue of the periodical within the volume
10
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
10
Pages from-to
2638-2647
UT code for WoS article
000710239500015
EID of the result in the Scopus database
2-s2.0-85115432750