Antiproliferative and Cytotoxic Activities of C-Geranylated Flavonoids from Paulownia tomentosa Steud. Fruit

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F21%3A88710" target="_blank" >RIV/60460709:41210/21:88710 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14160/21:00121331

Result on the web

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0045206821001747?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0045206821001747?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bioorg.2021.104797" target="_blank" >10.1016/j.bioorg.2021.104797</a>

Result language

angličtina

Original language name

Antiproliferative and Cytotoxic Activities of C-Geranylated Flavonoids from Paulownia tomentosa Steud. Fruit

Original language description

Prenylated or geranylated flavonoids have been studied for their promising antiproliferative and cytotoxic activities. Twelve natural geranylated flavonoids were isolated from the fruit of Paulownia tomentosa Steud. Their structures were elucidated using UV and IR spectroscopy, mass spectrometry, and 1D and 2D NMR spectroscopy. The absolute configurations were determined using NMR and circular dichroism. Seven of the compounds were characterized as new geranylated derivatives isolated from a natural source for the first time, namely 3-O-methyl-5-hydroxyisodiplacone, paulodiplacone A, tomentone II, tomentone B, tomentodiplacone P, paulodiplacone B, and tomentoflavone A. After 24 h of incubation at concentrations in the range 1-30 microM, the isolated compounds were tested for their antiproliferative and cytotoxic potentials against the human monocytic leukaemia cell line THP-1, using WST-1 and LDH assays, respectively. Almost all of the test compounds induced a concentration-dependent reduction in the

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10401 - Organic chemistry

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOORGANIC CHEMISTRY

ISSN

0045-2068

e-ISSN

1090-2120

Volume of the periodical

111

Issue of the periodical within the volume

June

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

0-0

UT code for WoS article

000656969400005

EID of the result in the Scopus database

2-s2.0-85104613367