Systematic bioinformatic analyses of nutrigenomic modifications by polyphenols associated with cardiometabolic health in humans—Evidence from targeted nutrigenomic studies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F21%3A88747" target="_blank" >RIV/60460709:41210/21:88747 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2072-6643/13/7/2326" target="_blank" >https://www.mdpi.com/2072-6643/13/7/2326</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu13072326" target="_blank" >10.3390/nu13072326</a>

Result language

angličtina

Original language name

Systematic bioinformatic analyses of nutrigenomic modifications by polyphenols associated with cardiometabolic health in humans—Evidence from targeted nutrigenomic studies

Original language description

Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also ident

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30308 - Nutrition, Dietetics

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrients

ISSN

2072-6643

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

28

Pages from-to

0-0

UT code for WoS article

000676308300001

EID of the result in the Scopus database

2-s2.0-85109006863