Impact of diethyl phthalate on freshwater planarian behaviour, regeneration, and antioxidant defence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F24%3A98353" target="_blank" >RIV/60460709:41210/24:98353 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.aquatox.2024.107110" target="_blank" >https://doi.org/10.1016/j.aquatox.2024.107110</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aquatox.2024.107110" target="_blank" >10.1016/j.aquatox.2024.107110</a>

Result language

angličtina

Original language name

Impact of diethyl phthalate on freshwater planarian behaviour, regeneration, and antioxidant defence

Original language description

Diethyl phthalate (DEP) has been widely used as a plasticiser in various consumer products, including cosmetics, personal care items, and pharmaceuticals, and recent studies reported a higher abundance of this priority phthalate in the aquatic environment. DEP is a potential endocrine disruptor, affecting immune systems in humans and wildlife even at low-level chronic exposure. As concern over phthalates increases globally, regulatory bodies focus more on their environmental impact. However, limited research is available, particularly using model organisms like planarians. Planarians are ideal for toxicological studies and may provide insightful information on pollutants' neurotoxic, developmental, and ecological effects, especially in freshwater environments where planarians play a vital role in ecosystem balance. Therefore, the objective of the current study was to examine the toxicity of DEP using the freshwater Dugesia sp., , as an experimental animal. The LC50 50 for the test organism was calculated using DEP concentrations of 800, 400, 200, 100, and 50 mu M, with an estimated LC50 50 of 357.24 mu M. Furthermore, planarians were exposed to sub-lethal DEP concentration (178.62 mu M) for one day as well as eight days to evaluate the impact of DEP on planarian locomotion, feeding behaviour, and regeneration ability. At sub-lethal concentration, locomotion and feeding ability were decreased, and regeneration was delayed. Furthermore, neuro-transmittance in planaria was altered by sub-lethal DEP concentration, as indicated by a reduced acetylcholinesterase (AChE) activity. DEP exposure induced oxidative damage in the tested planarians as shown by a marked increase in stress biomarkers, including lipid peroxidation levels and antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), and glutathione S-transferase (GST). Our study revealed that DEP exposure may prove fatal to freshwater organisms, such as planarians. The observed alterations in behaviour and regeneration ability demonstrate the severity of the effects exerted by DEP as a toxicant in aquatic ecosystems, thereby indicating the need to restrict its usage to protect aquatic environments.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10511 - Environmental sciences (social aspects to be 5.7)

Project

<a href="/en/project/QK21010207" target="_blank" >QK21010207: Diversification and strengthening the competitiveness of aquaculture by promoting aquaponics as an innovative technology for agricultural food production</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

AQUATIC TOXICOLOGY

ISSN

0166-445X

e-ISSN

1879-1514

Volume of the periodical

276

Issue of the periodical within the volume

NOV 2024

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

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UT code for WoS article

001334169700001

EID of the result in the Scopus database

2-s2.0-85205692946