The mutual interaction of ferulic acid and the gut microbiota
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41210%2F25%3A102219" target="_blank" >RIV/60460709:41210/25:102219 - isvavai.cz</a>
Result on the web
<a href="https://amsacta.unibo.it/id/eprint/8570/3/Book%20of%20Proceedings%201st%20INFOGUT%20ANNUAL%20MEETING%20complete%2024%2010%202025.pdf" target="_blank" >https://amsacta.unibo.it/id/eprint/8570/3/Book%20of%20Proceedings%201st%20INFOGUT%20ANNUAL%20MEETING%20complete%2024%2010%202025.pdf</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
The mutual interaction of ferulic acid and the gut microbiota
Original language description
Interindividual variability in the metabolism of dietary polyphenols, such as ferulic acid (FA), may influence health outcomes. This study aimed to identify distinct FA metabotypes using in vitro fecal fermentation of FA with samples from 18 healthy donors, followed by 1H NMR metabolite profiling and 16S rDNA microbiome analysis. Data from both platforms were processed independently and integrated using data fusion techniques. Donors were classified based on the timing and extent of FA degradation and production of microbial catabolites. Substantial variability was observed, with distinct patterns in the formation of key metabolites, including 3-(3-hydroxyphenyl)propionic acid and dihydroferulic acid. Metabotypes differed in fecal metabolite profiles and microbial activity. For example, early FA degraders showed higher valerate and lower amino acid levels, along with a reduced abundance of Turicibacter sanguinis. These findings support the existence of reproducible FA metabotypes and suggest that gut microbiota composition plays a key role in shaping individual metabolic responses. Funding. This work was supported by the Grant Agency of the Czech Republic (GACR 23– 04655S), METROFOOD-CZ research infrastructure project (MEYS Grants LM2018100 and "COST Action CA23110 “International networking on in vitro colon models simulating gut microbiota mediated interactions (INFOGUT).
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
—
OECD FORD branch
30308 - Nutrition, Dietetics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Book of Conference Proceedings 1 st INFOGUT Annual Meeting
ISBN
9788854972100
ISSN
—
e-ISSN
—
Number of pages
2
Pages from-to
91-92
Publisher name
University of Bologna
Place of publication
Bologna
Event location
Bologna
Event date
Jan 1, 2025
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
—