Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41330%2F20%3A85107" target="_blank" >RIV/60460709:41330/20:85107 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2227-9059/8/5/132" target="_blank" >https://www.mdpi.com/2227-9059/8/5/132</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biomedicines8050132" target="_blank" >10.3390/biomedicines8050132</a>
Alternative languages
Result language
angličtina
Original language name
Brassicasterol with Dual Anti-Infective Properties against HSV-1 and Mycobacterium tuberculosis, and Cardiovascular Protective Effect: Nonclinical In Vitro and In Silico Assessments
Original language description
While few studies have revealed the biological properties of brassicasterol, a phytosterol, against some biological and molecular targets, it is believed that there are still many activities yet to be studied. In this work, brassicasterol exerts a therapeutic utility in an in vitro setting against herpes simplex virus type 1 (HSV 1) and Mycobacterium tuberculosis (Mtb) as well as a considerable inhibitory property against human angiotensin converting enzyme (ACE) that plays a dynamic role in regulating blood pressure. The antireplicative effect of brassicasterol against HSV 1 is remarkably detected (50 percent inhibitory concentration (IC50) 1,2 mu M, selectivity index (SI) 41,7), while the potency of its effect is ameliorated through the combination with standard acyclovir with proper SI (IC50 0,7 mu M, SI 71,4). Moreover, the capacity of this compound to induce an adequate level of antituberculosis activity against all Mtb strains examined (minimum inhibitory concentration values ranging from 1,9 t
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedicines
ISSN
2227-9059
e-ISSN
2227-9059
Volume of the periodical
8
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1-12
UT code for WoS article
000540842200038
EID of the result in the Scopus database
2-s2.0-85087088356