Derivatization of Methylglyoxal for LC-ESI-MS AnalysisStability and Relative Sensitivity of Different Derivatives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41340%2F18%3A78127" target="_blank" >RIV/60460709:41340/18:78127 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3390/molecules23112994" target="_blank" >http://dx.doi.org/10.3390/molecules23112994</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules23112994" target="_blank" >10.3390/molecules23112994</a>
Alternative languages
Result language
angličtina
Original language name
Derivatization of Methylglyoxal for LC-ESI-MS AnalysisStability and Relative Sensitivity of Different Derivatives
Original language description
The great research interest in the quantification of reactive carbonyl compounds RCCs, such as methylglyoxal MGO in biological and environmental samples, is reflected by the fact that several publications have described specific strategies to perform this task. Thus, many reagents have also been reported for the derivatization of RCCs to effectively detect and quantify the resulting compounds using sensitive techniques such as liquid chromatography coupled with mass spectrometry LCMS. However, the choice of the derivatization protocol is not always clear, and a comparative evaluation is not feasible because detection limits from separate reports and determined with different instruments are hardly comparable. Consequently, for a systematic comparison, we tested 21 agents in one experimental setup for derivatization of RCCs prior to LCMS analysis. This consisted of seven commonly employed reagents and 14 similar reagents, three of which were designed and synthesized by us. All reagents were probed for
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
11 - 2994
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
1-19
UT code for WoS article
000451641900266
EID of the result in the Scopus database
2-s2.0-85056655414