Increased Mutation Rate Is Linked to Genome Reduction in Prokaryotes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60460709%3A41340%2F20%3A84613" target="_blank" >RIV/60460709:41340/20:84613 - isvavai.cz</a>
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/32763167/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/32763167/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cub.2020.07.034" target="_blank" >10.1016/j.cub.2020.07.034</a>

Result language
angličtina
Original language name
Increased Mutation Rate Is Linked to Genome Reduction in Prokaryotes
Original language description
The evolutionary processes that drive variation in genome size across the tree of life remain unresolved. Effective population size (N-e) is thought to play an important role in shaping genome size 1-3-a key example being the reduced genomes of insect endosymbionts, which undergo population bottlenecks during transmission 4. However, the existence of reduced genomes in marine and terrestrial prokaryote species with large N-e indicate that genome reduction is influenced by multiple processes 3. One candidate process is enhanced mutation rate, which can increase adaptive capacity but can also promote gene loss. To investigate evolutionary forces associated with prokaryotic genome reduction, we performed molecular evolutionary and phylogenomic analyses of nine lineages from five bacterial and archaeal phyla. We found that gene-loss rate strongly correlated with synonymous substitution rate (a proxy for mutation rate) in seven of the nine lineages. However, gene-loss rate showed weak or no correlation wi
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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