Novel heterocyclic Troger´ s base derivatives containing N-methylpyrrole units

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F03%3A00007617" target="_blank" >RIV/60461373:22310/03:00007617 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22340/03:00007617

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel heterocyclic Troger´ s base derivatives containing N-methylpyrrole units

Original language description

Novel analogues of Troger's base were prepared regioselectively from 4-amono-N-methylpyrrole carboxylates in good yield. Catalytic hydrogenation ofdibenzyl-4,9-methano-l,6-dimethyl-4,5.9.10-tetrahydro-1H,6H-dipyrrolo- [3,2/b:3',2'-fII1,5]diazocin- 2,7-dicarboxylate 2b led to 4,9-methano-1,6-dimethyl-4,5,9,10-1H,6H-dipyrrolo-[3,2-b:3',2'-f][1,5]diazocin-2,7-dicargoxylic acid 3 which was used for the preparation of Troger's base derivatives of natural antibiotics via an amide protocol. The novel heterocyclic Troger's bases were characterized by a variety of spectroscopic techniques and compound 2b by X-ray crystallography. Incorporation of guanidine as the terminal group in the N-methylpyrrole Troger's base skeleton opens the possibility for preparationof water soluble derivatives.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GA309%2F02%2F1193" target="_blank" >GA309/02/1193: GASEOUS SIGNALING IN THE NERVOUS SYSTEM (The role of NO and CO in the model system)</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2003

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tetrahedron Letters

ISSN

0040-4039

e-ISSN

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Volume of the periodical

44

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

2083-2086

UT code for WoS article

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EID of the result in the Scopus database

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