6-Magnesiated Purines: Preparation and Reaction with Aldehydes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F03%3A00008311" target="_blank" >RIV/60461373:22310/03:00008311 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
6-Magnesiated Purines: Preparation and Reaction with Aldehydes
Original language description
Halogen-metal exchange reaction of 9-benzyl-6-iodopurine with iPrMgCl in toluene at -80 degreesC proceeds almost quantitatively. Such a purine-derived Grignard reagent reacts selectively with aldehydes in toluene, giving the corresponding alcohols in 25-62% yield, while other functional groups such as ketones, esters, and nitriles do not react under these conditions. The reaction can be extended to protected 6-iodopurine ribonucleoside.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F03%2F0035" target="_blank" >GA203/03/0035: Synthesis of novel purine derivatives bearing functionalized C-substituents in the position 6</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Organic Letters
ISSN
1523-7060
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
23
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
4289-4291
UT code for WoS article
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EID of the result in the Scopus database
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