Metergoline II ? structure solution from powder diffraction data with preferred orientation and from microcrystal.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F08%3A00020094" target="_blank" >RIV/60461373:22310/08:00020094 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/08:00309533

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Metergoline II ? structure solution from powder diffraction data with preferred orientation and from microcrystal.

Original language description

Metergoline is a dopamine agonist and serotonin antagonist used both in human and veterinary medicine. In addition to the previously known crystalline form a new polymorph, which crystallizes from aqueous solution, was found. Since it was initially impossible to prepare a single crystal of quality suitable for single crystal X-ray diffraction measurements using a conventional laboratory source, the structure was solved from powder diffraction data using synchrotron radiation. The structure determinationalso included solving the effects of preferred orientation. Characterization was simultaneously done by solid-state NMR spectroscopy. Finally, a small single crystal suitable for synchrotron diffraction was found after numerous tries. Crystal structuredetermination using this single crystal confirmed the powder-based solution. Comparison of information obtained by different experimental methods (powder diffraction, ssNMR, single crystal diffraction) was made

Czech name

Struktura fáze Metergolin II z práškové difrakce ovlivněné preferenční orientací.

Czech description

Byla vyřešena struktura nové fáze látky Metergolin II. Pro řešení byla použita prášková data naměřená na synchrotornu, difrakce na mikrokrystalu a NMR pevné látky.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Struct.Chem.

ISSN

1040-0400

e-ISSN

—

Volume of the periodical

—

Issue of the periodical within the volume

19

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

—

UT code for WoS article

000257332800020

EID of the result in the Scopus database

—