SYNTHESIS AND PROPERTIES OF NOVEL BIOLOGICALLY INTERESTING POLYCYCLIC 1,3,4-OXADIAZOLES CONTAINING ACRIDINE/ACRIDONE MOIETIES

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F09%3A00021772" target="_blank" >RIV/60461373:22310/09:00021772 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

SYNTHESIS AND PROPERTIES OF NOVEL BIOLOGICALLY INTERESTING POLYCYCLIC 1,3,4-OXADIAZOLES CONTAINING ACRIDINE/ACRIDONE MOIETIES

Original language description

A series of polycyclic 1,3,4-oxadiazoles bearing acridine and acridone pharmacophores were synthesized as potential noncovalent DNA-binding and antitumor agents. The synthesis of oxadiazoles with acridone moiety was performed exploring oxidative cyclization of corresponding aldimines via bromine and the acridine derivatives by cyclization of acylthiosemicarbazides with mercuric oxide. The spectroscopic properties of the compounds in the case of acridonoxadiazoles showed an efficient binding activity toDNA (K = 5.3-9.2 x 10(4) M-1), whereas the acridine analogues are suitable as biomarkers. The structure of compounds were characterized by spectral methods (UV-vis, IR, H-1, C-13, and 2D NMR) and quantum-chemical calculations (DFT, ZINDO).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Heterocycles

ISSN

0385-5414

e-ISSN

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Volume of the periodical

77

Issue of the periodical within the volume

2

Country of publishing house

JP - JAPAN

Number of pages

17

Pages from-to

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UT code for WoS article

000264490200035

EID of the result in the Scopus database

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