Opportunities offered by chiral éta6-arene/N-arylsulfonyl-diamine-Ru(II) catalysts in the asymmetric transfer hydrogenation of ketones and imines

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F11%3A43891934" target="_blank" >RIV/60461373:22310/11:43891934 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3390/molecules16075460" target="_blank" >http://dx.doi.org/10.3390/molecules16075460</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules16075460" target="_blank" >10.3390/molecules16075460</a>

Result language

angličtina

Original language name

Opportunities offered by chiral éta6-arene/N-arylsulfonyl-diamine-Ru(II) catalysts in the asymmetric transfer hydrogenation of ketones and imines

Original language description

A review. Methods for the asym. transfer hydrogenation (ATH) of ketones and imines were intensively studied and developed. Of foremost interest is the use of Noyori's [RuCl(éta6-arene)(N-TsDPEN)] complexes in the presence of a hydrogen donor (i-PrOH, formic acid). These complexes found numerous practical applications and were extensively modified. The resulting derivs. were heterogenized, used in ATH in water or ionic liqs. and even some attempts were made to approach the properties of biocatalysts. Therefore, an appropriate modification of the catalyst that suits the specific requirements for the reaction conditions is very often readily available. The mechanism of the reaction was also explored to a great extent. Model substrates, acetophenone (a ketone) and 6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline (an imine), are both reduced by this Ru catalytic system with almost perfect selectivity. However, in each case the major product is a different enantiomer (S - for an alc., R - for

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/GA104%2F09%2F1497" target="_blank" >GA104/09/1497: Study of modern aspects of asymmetric hydrogenation of imines</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecules

ISSN

1420-3049

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

35

Pages from-to

5460-5495

UT code for WoS article

000293073900011

EID of the result in the Scopus database

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