Synthesis and structural studies of flavin and alloxazine adducts with O-nucleophiles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F11%3A43892807" target="_blank" >RIV/60461373:22310/11:43892807 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/11:00368922 RIV/60461373:22810/11:43892807
Result on the web
<a href="http://dx.doi.org/10.1016/j.molstruc.2011.08.002" target="_blank" >http://dx.doi.org/10.1016/j.molstruc.2011.08.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molstruc.2011.08.002" target="_blank" >10.1016/j.molstruc.2011.08.002</a>

Result language
angličtina
Original language name
Synthesis and structural studies of flavin and alloxazine adducts with O-nucleophiles
Original language description
Five flavin (isoalloxazine) and alloxazine adducts with O-nucleophiles, 5-ethyl-4a-hydroxy-3,7,8,10-tetramethyl-4a,5-dihydroisoalloxazine (1a-OH), 5-ethyl-4a-hydroxy-3,10-dimethyl-4a,5-dihydroisoalloxazine (1b-OH), 5-ethyl-4a-methoxy-3,10-dimethyl-4a,5-dihydroisoalloxazine (1b-OMe), 5-ethyl-4a-hydroxy-1,3-dimethyl-4a,5-dihydroalloxazine (2a-OH) and 5-ethyl-4a-methoxy-1,3-dimethyl-4a,5-dihydroalloxazine (2a-OMe) were prepared from the corresponding salts, 5-ethyl-3,7,8,10-tetramethylisoalloxazinium (la),5-ethyl-3,10-dimethylisoalloxazinium (1b) and 5-ethyl-1,3-dimethylalloxazinium (2a) perchlorates by the addition of a nucleophile (water or methanol) and triethylamine as a base. The prepared adducts represent artificial analogs of Flavin cofactor derivatives which are essential for the functioning of flavoenzymes. They were characterized by (1)H and (13)C NMR, HR-MS and UV-VIS spectra. In the cases of la-OH, 1b-OH, and 2a-OMe, the crystal structures were determined by X-ray diffraction
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/GA203%2F07%2F1246" target="_blank" >GA203/07/1246: Chiral flavinium salts as organocatalysts for enantioselective sulfoxidations and N-oxidations</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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