A new way of solid dosage form samples preparation for SEM and FTIR using microtome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F13%3A43895356" target="_blank" >RIV/60461373:22310/13:43895356 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10837450.2013.788515" target="_blank" >http://dx.doi.org/10.3109/10837450.2013.788515</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2013.788515" target="_blank" >10.3109/10837450.2013.788515</a>

Result language
angličtina
Original language name
A new way of solid dosage form samples preparation for SEM and FTIR using microtome
Original language description
Rapid and correct production of generic solid dosage forms requires a large amount of analytical data and conclusions. Modern analytical techniques have a good resolution and accuray and allow obtaining a lot of information about the original products. Scanning electron microscopy (SEM) is used for observation infrared (FTIR) spectroscopy mapping allows determining the distribution and characterization of individual components in a solid dosage form. However, the samples prepared by common way, using scalpel or tablet splitter, are not good enough. It was the reason for development of a new and better method of sample preparation, which uses microtome. Well-prepared samples analyzed by SEM and FTIR mapping allow to determine a solid dosage form formulation, excipient content and distribution of excipient and active pharmaceutical ingredient.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CI - Industrial chemistry and chemical engineering
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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