Novel carbamoyl type quinine and quinidine based chiral anion exchangers implementing alkyne-azide cycloaddition immobilization chemistry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897209" target="_blank" >RIV/60461373:22310/14:43897209 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0021967314002568" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0021967314002568</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chroma.2014.02.026" target="_blank" >10.1016/j.chroma.2014.02.026</a>
Alternative languages
Result language
angličtina
Original language name
Novel carbamoyl type quinine and quinidine based chiral anion exchangers implementing alkyne-azide cycloaddition immobilization chemistry
Original language description
The synthesis and chromatographic evaluation of a series of new Cinchona derived chiral weak anionexchangers is presented. Huisgen Cu(I) mediated alkyne-azide cycloaddition, so-called click chemistry,was used as an immobilization strategy. In this way itwas possible to immobilize about 90% of offeredselector via 1,2,3-triazole linker, which displays a more efficient way of binding the selector to modifiedsilica compared to common radical mediated thiol-ene addition. Problems associated with potentialradical scavenging properties of chiral selectors thereby could be circumvented. The evaluation of thesynthesized chiral stationary phases regarding chromatographic behavior was carried out using polarorganic mode mobile phase composition and a set of representative chiral organic acids. Different loadingdensities revealed an optimum selector density of about 310 mol/g chiral stationary phase with respectto resolution and selectivity. A decrease of performance was observed for higher loadi
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Chromatography A
ISSN
0021-9673
e-ISSN
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Volume of the periodical
1337
Issue of the periodical within the volume
18.2.2014
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
85-94
UT code for WoS article
000334082200012
EID of the result in the Scopus database
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