Hot-Stage Microscopy for Determination of API Particles in a Formulated Tablet
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F14%3A43897878" target="_blank" >RIV/60461373:22310/14:43897878 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2014/832452" target="_blank" >http://dx.doi.org/10.1155/2014/832452</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/832452" target="_blank" >10.1155/2014/832452</a>
Alternative languages
Result language
angličtina
Original language name
Hot-Stage Microscopy for Determination of API Particles in a Formulated Tablet
Original language description
Although methods exist to readily determine the particle size distribution (PSD) of an active pharmaceutical ingredient (API) before its formulation into a final product, the primary challenge is to develop a method to determine the PSD of APIs in a finished tablet. To address the limitations of existing PSD methods, we used hot-stage microscopy to observe tablet disintegration during temperature change and, thus, reveal the API particles in a tablet. Both mechanical and liquid disintegration were evaluated after we had identified optimum milling time for mechanical disintegration and optimum volume of water for liquid disintegration. In each case, hot-stage micrographs, taken before and after the API melting point, were compared with image analysis software to obtain the PSDs. Then, the PSDs of the APIs from the disintegrated tablets were compared with the PSDs of raw APIs. Good agreement was obtained, thereby confirming the robustness of our methodology. The availability of such a me
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOMED RESEARCH INTERNATIONAL
ISSN
2314-6133
e-ISSN
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Volume of the periodical
2014
Issue of the periodical within the volume
neuveden
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
"neuveden"
UT code for WoS article
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EID of the result in the Scopus database
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