Salt-kneading: alternative sizing of active pharmaceutical ingredients?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43899854" target="_blank" >RIV/60461373:22310/15:43899854 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10837450.2015.1086371" target="_blank" >http://dx.doi.org/10.3109/10837450.2015.1086371</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2015.1086371" target="_blank" >10.3109/10837450.2015.1086371</a>
Alternative languages
Result language
angličtina
Original language name
Salt-kneading: alternative sizing of active pharmaceutical ingredients?
Original language description
The most of currently produced active pharmaceutical ingredients (APIs) are poorly soluble in the human body. One of the options how to increase their dissolution rate is reducing their particle size. If very small particles of API are desired, traditional milling methods often cause smeared, agglomerated or non-flowing particles due to the forces applied. We tried to compare some of milling methods with the salt-kneading method, which is not typically used in the pharmaceutical industry. Salt-kneading process is driven by several variable parameters (e.g. the amount, hardness and particle size of the salt-kneading material), which influence the degree of size reduction of API particles which are chafed by a surplus of salt-kneading material. A model poorly-soluble API was separately processed with oscillation mill, vibratory mill and kneader; and the morphology, size distribution and solid form of prepared particles were analyzed. Our basic variation of salt-kneading parameters showed the potential of the saltkneading method, which appears a very effective method of API controlled reduction. The final size can be modified according to the amount and properties of the salt-kneading material. The availability of such a method equips pharmaceutical scientists with a size-reduction method that provides very small, rounded and free-flowing particles of the poorly soluble API and reduces non-preferred needle shape.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmaceutical Development and Technology
ISSN
1083-7450
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
972-979
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-84941243053