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Salt-kneading: alternative sizing of active pharmaceutical ingredients?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43899854" target="_blank" >RIV/60461373:22310/15:43899854 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.3109/10837450.2015.1086371" target="_blank" >http://dx.doi.org/10.3109/10837450.2015.1086371</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3109/10837450.2015.1086371" target="_blank" >10.3109/10837450.2015.1086371</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Salt-kneading: alternative sizing of active pharmaceutical ingredients?

  • Original language description

    The most of currently produced active pharmaceutical ingredients (APIs) are poorly soluble in the human body. One of the options how to increase their dissolution rate is reducing their particle size. If very small particles of API are desired, traditional milling methods often cause smeared, agglomerated or non-flowing particles due to the forces applied. We tried to compare some of milling methods with the salt-kneading method, which is not typically used in the pharmaceutical industry. Salt-kneading process is driven by several variable parameters (e.g. the amount, hardness and particle size of the salt-kneading material), which influence the degree of size reduction of API particles which are chafed by a surplus of salt-kneading material. A model poorly-soluble API was separately processed with oscillation mill, vibratory mill and kneader; and the morphology, size distribution and solid form of prepared particles were analyzed. Our basic variation of salt-kneading parameters showed the potential of the saltkneading method, which appears a very effective method of API controlled reduction. The final size can be modified according to the amount and properties of the salt-kneading material. The availability of such a method equips pharmaceutical scientists with a size-reduction method that provides very small, rounded and free-flowing particles of the poorly soluble API and reduces non-preferred needle shape.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Pharmaceutical Development and Technology

  • ISSN

    1083-7450

  • e-ISSN

  • Volume of the periodical

    21

  • Issue of the periodical within the volume

    8

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

    972-979

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-84941243053