Amine functionalized carbon nanoparticles grafted biopolymer for cell adhesion and proliferation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F15%3A43900454" target="_blank" >RIV/60461373:22310/15:43900454 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Amine functionalized carbon nanoparticles grafted biopolymer for cell adhesion and proliferation
Original language description
Various carbon nanostructures are widely researched for use in number of medical applications. We evaluated the surface properties and cell-substrate interactions of three types of amine functionalized carbon nanoparticles (CNPs) grafted on biopolymer film. Poly-L-lactic acid, in form of polymer film, was treated in an inert argon plasma discharge and, subsequently, grafted with functionalized carbon nanoparticles. Selected samples were thermally stressed during or following the grafting procedure. The surface properties were studied using multiple methods, including goniometry, atomic force microscopy and X-ray photoelectron spectroscopy. Cell-substrate interactions were determined in vitro by studying adhesion, proliferation and viability of vascular smooth muscle cells (VSMCs) from the aorta of a rat. Cell-substrate interactions on pristine and modified substrates were compared to standard tissue culture polystyrene (TCPS). Our results show that CNPs affect surface morphology and wettability and therefore adhesion, proliferation and viability of cultured cells.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
JJ - Other materials
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NV15-33018A" target="_blank" >NV15-33018A: Application of adipose tissue-derived stem cells obtained by liposuction in tissue engineering</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů