Structure, mechanical characteristics and in vitro degradation, cytotoxicity, genotoxicity and mutagenicity of novel biodegradable Zn-Mg alloys

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F16%3A43900033" target="_blank" >RIV/60461373:22310/16:43900033 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.msec.2015.08.015" target="_blank" >http://dx.doi.org/10.1016/j.msec.2015.08.015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.msec.2015.08.015" target="_blank" >10.1016/j.msec.2015.08.015</a>

Result language

angličtina

Original language name

Structure, mechanical characteristics and in vitro degradation, cytotoxicity, genotoxicity and mutagenicity of novel biodegradable Zn-Mg alloys

Original language description

Zn-(0-1.6)Mg (in wt.%) alloys were prepared by hot extrusion at 300 degrees C. The structure, mechanical properties and in vitro biocompatibility of the alloys were investigated. The hot-extruded magnesium-based WE43 alloy was used as a control. Mechanical properties were evaluated by hardness, compressive and tensile testing. The cytotoxicity, genotoxicity (comet assay) and mutagenicity (Ames test) of the alloy extracts and ZnCl2 solutions were evaluated with the use of murine fibroblasts L929 and human osteosarcoma cell line U-2 OS. The microstructure of the Zn alloys consisted of recrystallized Zn grains of 12 11111 in size and fine Mg2Zn1.1 particles arranged parallel to the hot extrusion direction. Mechanical tests revealed that the hardness and strength increased with increasing Mg concentration. The Zn-0.8 Mg alloys showed the best combination of tensile mechanical properties (tensile yield strength of 203 MPa, ultimate tensile strength of 301 MPa and elongation of 15%). At higher Mg concentrations the plasticity of Zn-Mg alloys was deteriorated. Cytotoxicity tests with alloy extracts and ZnCl2 solutions proved the maximum safe Zn2+ concentrations of 120 mu M and 80 mu M for the 0-2 OS and L929 cell lines, respectively. Ames test with extracts of alloys indicated that the extracts were not mutagenic. The comet assay demonstrated that 1-day extracts of alloys were not genotoxic for U-2 OS and L929 cell lines after 1-day incubation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

JG - Metallurgy, metal materials

OECD FORD branch

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Project

<a href="/en/project/GBP108%2F12%2FG043" target="_blank" >GBP108/12/G043: Interface controlled properties of micro/nanocrystalline materials for advanced structural applications, biodegradable implants and hydrogen storage</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Materials science and engineering C

ISSN

0928-4931

e-ISSN

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Volume of the periodical

neuveden

Issue of the periodical within the volume

28

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

12

Pages from-to

24-35

UT code for WoS article

000364247500004

EID of the result in the Scopus database

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