Black phosphorus nanoparticles as a novel fluorescent sensing platform for nucleic acid detection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F17%3A43913407" target="_blank" >RIV/60461373:22310/17:43913407 - isvavai.cz</a>

Result on the web

<a href="http://pubs.rsc.org/en/content/articlehtml/2017/qm/c6qm00341a" target="_blank" >http://pubs.rsc.org/en/content/articlehtml/2017/qm/c6qm00341a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6qm00341a" target="_blank" >10.1039/c6qm00341a</a>

Result language

angličtina

Original language name

Black phosphorus nanoparticles as a novel fluorescent sensing platform for nucleic acid detection

Original language description

Two-dimensional black phosphorus is an emerging material. For the past two years, black phosphorus has attracted the attention of the scientific community due to its promising applications in electronic devices and biosensors. In this work, black phosphorus nanoparticles (BPNPs) derived from a facile, one-step synthesis method were successfully employed as nanofluorophores in the development of a fluorescent sensing platform for DNA detection, for the first time. This detection strategy exploits the differences in affinities of labelled single-stranded and double-stranded DNA oligonucleotides towards spontaneous self-assembly with black phosphorus nanoparticles. A wide linear detection range with good linearity (r = 0.91) spanning from 4 pM to 4000 pM was achieved with the constructed nanosensor, including the ability to distinguish triple nucleotide polymorphism. Moreover, high sensitivity was also demonstrated with a low limit of detection (LOD = 5.9 pM) and limit of quantification (LOQ = 19.7 pM). This paper demonstrates a proof of concept that black phosphorus possesses promising potential for biosensing applications, in particular as DNA nanobiosensors, and the reported findings would be significant in encouraging further research work into the development of biomedical devices and technologies based on black phosphorus.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

<a href="/en/project/GA15-09001S" target="_blank" >GA15-09001S: Chemical modifications of graphene based materials: Synthesis of graphane and halogengraphene</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Materials Chemistry Frontiers

ISSN

2052-1537

e-ISSN

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Volume of the periodical

1

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

1130-1136

UT code for WoS article

000412450600013

EID of the result in the Scopus database

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