SERS platform for detection of lipids and disease markers prepared using modification of plasmonic-active gold gratings by lipophilic moieties

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916455" target="_blank" >RIV/60461373:22310/18:43916455 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/18:10376024
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0925400518304945?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0925400518304945?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.snb.2018.03.016" target="_blank" >10.1016/j.snb.2018.03.016</a>

Result language
angličtina
Original language name
SERS platform for detection of lipids and disease markers prepared using modification of plasmonic-active gold gratings by lipophilic moieties
Original language description
New functional SERS platform for effective detection of lipophilic disease markers was proposed and realized. The work was aimed at the achievement of highly-reproducible SERS results obtained in shorter measuring times. The homogeneous plasmon distribution was achieved through the introduction of large area surface plasmon-polariton supported substrate with a good smearing of plasmon intensity along the working substrate area. Homogeneous distribution of targeted lipophilic molecules on the SERS surface was realized through the surface grafting with alkylaryl moieties of various carbon chain lengths via diazonium chemistry. The process of modification was followed and confirmed by XPS and Raman methods. The functionality of created SERS substrates was studied by the contact angle measurement and CVA methods. The possibility of detection of two biomedically significant molecules (squalene and beta-sitosterol) was examined. Dependence of the SERS results on the aliphatic chain lengths was tested in the terms of targeted molecules SERS intensity and reproducibility. The prepared SERS substrates were found to be suitable for sensing of squalene and beta-sitosterol at the biorelevant mu M concentration level.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20501 - Materials engineering

Project
<a href="/en/project/GA15-19485S" target="_blank" >GA15-19485S: Polymer-based smart coatings</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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