COMPARATIVE STUDY OF BIOLOGICAL RESPONSE OF Ag AND Pd NANOWIRE ARRAYS SUPPORTED ON POLYETHYLENE NAPHTHALATE FOR MEDICAL APPLICATIONS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F18%3A43916584" target="_blank" >RIV/60461373:22310/18:43916584 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
COMPARATIVE STUDY OF BIOLOGICAL RESPONSE OF Ag AND Pd NANOWIRE ARRAYS SUPPORTED ON POLYETHYLENE NAPHTHALATE FOR MEDICAL APPLICATIONS
Original language description
In recent days, advancements in nanotechnology ensure everyday applications of nanostructured noble metals, especially silver. Particularly in the medicinal applications, where they profit from their unique antibacterial effects, a serious risk of cytotoxic side-effects may occur. In this work, we studied biological (antibacterial and cytotoxic) response of commonly used silver nanostructures (nanowires, NWs), and compared them with Pd ones, as their possibly safer alternative. Both metal nanostructures were supported on biocompatible polymer - polyethylene naphthalate. The surface of metal/polymer composites was thoroughly characterized by XPS, FIB-SEM and AFM. Thereafter, biological testing of the samples was accomplished. Antibacterial properties of both, Ag and Pd NWs were examined and mutually compared by using Gram-negative bacteria Escherichia coli and Gram-positive Staphylococcus epidermidis, which commonly cause hospital-acquired infections. Finally, the comparative cytotoxic study of both types of composites was carried out using mouse embryonic fibroblasts. Such approach was chosen to determine, whether Pd nanostructures might compete with Ag ones in their medical applications.
Czech name
—
Czech description
—
Classification
Type
D - Article in proceedings
CEP classification
—
OECD FORD branch
20501 - Materials engineering
Result continuities
Project
<a href="/en/project/GA17-10907S" target="_blank" >GA17-10907S: Environmental impact of noble metal nanoparticles</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Nanocon 2017
ISBN
978-80-87294-81-9
ISSN
—
e-ISSN
neuvedeno
Number of pages
6
Pages from-to
627-632
Publisher name
Tanger s.r.o.
Place of publication
Ostrava
Event location
Brno
Event date
Oct 18, 2017
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000452823300103