PEGylated gold nanoparticles: Stability, cytotoxicity and antibacterial activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43918406" target="_blank" >RIV/60461373:22310/19:43918406 - isvavai.cz</a>
Alternative codes found
RIV/44555601:13440/19:43894735 RIV/00216208:11110/19:10383266 RIV/00216208:11140/19:10383266 RIV/00216208:11320/19:10383266
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0927775718312299?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0927775718312299?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.colsurfa.2018.09.083" target="_blank" >10.1016/j.colsurfa.2018.09.083</a>
Alternative languages
Result language
angličtina
Original language name
PEGylated gold nanoparticles: Stability, cytotoxicity and antibacterial activity
Original language description
Designing safe nanomaterials is nowadays a critical issue. A way to prepare PEGylated Au NPs by sputtering of Au into pure (PEG), thiol (PEG-SH) and amine terminated polyethylene glycols (PEG-NH2) was explored. Structural characterizations, aging and thermal stability were performed using transmission electron microscope (TEM/HRTEM) and UV-vis spectroscopy. By TEM we observed that spherical Au NPs were successfully prepared with average diameter of 1.5-5.9 nm. HRTEM revealed that a majority of them is rather of a round or irregular shape with a frequent multiple twinning. Dynamic light scattering as well as TEM confirmed that Au NPs have monodal size distribution. According to atomic absorption spectroscopy, concentration of gold increases with sputtering time and does not change with aging time. PEG-SH exhibited loss of SPR absorption band in UV-vis spectrum because of the small NP size (1.5 nm). PEG and PEG-NH2 showed good thermal and aging stability. No significant antibacterial effect of any type of the studied Au NPs has been discovered. Cytotoxic effect on osteoblasts was determined only with the highest concentration of Au NP with PEG and PEG-NH2 stabilization. Au NPs stabilized by PEG-SH showed the overall optimal physical and biological properties for drug delivery applications.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20501 - Materials engineering
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Colloids and Surfaces A: Physicochemical and Engineering Aspects
ISSN
0927-7757
e-ISSN
—
Volume of the periodical
560
Issue of the periodical within the volume
JAN 5 2019
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
9
Pages from-to
26-34
UT code for WoS article
000451048400004
EID of the result in the Scopus database
—