A two-phase gradual silver release mechanism from a nanostructured TiAlV surface as a possible antibacterial modification in implants
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43919507" target="_blank" >RIV/60461373:22310/19:43919507 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1567539418303487?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1567539418303487?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bioelechem.2019.01.003" target="_blank" >10.1016/j.bioelechem.2019.01.003</a>
Alternative languages
Result language
angličtina
Original language name
A two-phase gradual silver release mechanism from a nanostructured TiAlV surface as a possible antibacterial modification in implants
Original language description
Titanium biomaterials are widely used in the medical field due to their biocompatibility and excellent corrosion and mechanical resistance. However, these materials have no antibacterial properties. To obtain an antibacterial active surface, a nanostructure of Ti6Al4V alloy was created. This specific nanostructure contained nanotubes and micro-cavities and was used as a substrate for silver anchoring. The electrochemical approach to silver reduction was studied. It is a common approach for silver deposition and in this work, inhomogeneities in the nanostructure were used as a preferential area for silver localisation. The galvanostatic regimen of deposition allowed for a technically quantitative process and the required silver placement. The experimental conditions used enabled testing and silver dissolution rate evaluation within a reasonable time span. Based on the corrosion and analytical results (EDS, XPS and ICP-MS), a two-phase silver release mechanism was confirmed. The openings of the individual nanotubes were filled with silver nanoparticles, whose release was relatively fast. By contrast, the silver anchored inside the cavities allowed the silver to release gradually. Antibacterial efficiency against Staphylococcus aureus and Escherichia coli was successfully demonstrated. Cytotoxicity testing with murine fibroblasts showed cell metabolic activity far above the normative limit of 70%. (C) 2019 Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
<a href="/en/project/NV15-27726A" target="_blank" >NV15-27726A: Technologies of nano-tubes and nano-silver for antibacterial surface treatment of orthopaedic implants</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioelektrochemistry
ISSN
1567-5394
e-ISSN
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Volume of the periodical
127
Issue of the periodical within the volume
June
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
26-34
UT code for WoS article
000464481700004
EID of the result in the Scopus database
2-s2.0-85059841128