Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F20%3A43919247" target="_blank" >RIV/60461373:22310/20:43919247 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/19:00518986 RIV/00216224:14310/19:00113379
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11356-019-06568-y" target="_blank" >https://link.springer.com/article/10.1007%2Fs11356-019-06568-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11356-019-06568-y" target="_blank" >10.1007/s11356-019-06568-y</a>
Alternative languages
Result language
angličtina
Original language name
Epoxidation is the preferred pathway of first-stage metabolism of abiraterone acetate in brown bullhead (Ameiurus nebulosus)
Original language description
Twenty juvenile individuals of brown bullhead (Ameiurus nebulosus), average weight 77 g, were fed by abiraterone acetate prodrug dissolved in olive oil via gastric probe. Dose applied was 3 mg/10 g fish weight. After feeding, they were let out into aquarium and kept there for 3 days. Aquarium water containing excreted metabolites was extracted, and sample was purified and finally analyzed by means of HPLC/MS. Expected both primary (products of hydroxylation) and secondary (products of glucuronidation and sulfatation) metabolites of abiraterone acetate were identified. The NMR measurement of one of the prevailing metabolites presumed to be one of possible hydroxy-abiraterones discovered that it is not hydroxy-abiraterone but abiraterone 16,17-epoxide. Closer analysis of MS2 and MS3 spectra revealed that one of presumed hydroxy-abiraterone acetates and also some secondary metabolites are probably 16,17-epoxides.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10511 - Environmental sciences (social aspects to be 5.7)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Science and Pollution Research
ISSN
0944-1344
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
34
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
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UT code for WoS article
000492722200002
EID of the result in the Scopus database
2-s2.0-85074486632