Complexation of cathinones by 4-tert-butylcalix[4]arene tetra-acetate as a possible technique for forensic analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F20%3A43921671" target="_blank" >RIV/60461373:22310/20:43921671 - isvavai.cz</a>
Alternative codes found
RIV/67985858:_____/20:00506022 RIV/60461373:22330/20:43921671 RIV/60461373:22340/20:43921671 RIV/60461373:22810/20:43921671
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs11419-019-00489-8" target="_blank" >https://link.springer.com/article/10.1007%2Fs11419-019-00489-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11419-019-00489-8" target="_blank" >10.1007/s11419-019-00489-8</a>
Alternative languages
Result language
angličtina
Original language name
Complexation of cathinones by 4-tert-butylcalix[4]arene tetra-acetate as a possible technique for forensic analysis
Original language description
Purpose: Cathinone derivatives are new psychoactive substance(s) (NPSs) with amphetamine-like effects and currently represent a great problem for public health. For this reason it is necessary to develop new sensitive, selective fast and inexpensive methods for large-scale screening of NPSs. The purpose of this study was to evaluate the capabilities of 4-tert-butylcalix[4]arene tetra-acetate as a receptor of potentiometric sensor to recognize NPSs based on cathinone derivatives and one aminoindane for comparison. Methods: Potentiometry was used to determine the selectivity of a 4-tert-butylcalix[4]arene tetra-acetate towards cathinone derivatives. Density functional theory (DFT) computations and nuclear magnetic resonance (NMR) titration were used to explain the binding modes of the calix[4]arene derivative towards selected NPSs. Results: The basic binding mode of the calix[4]arene derivative for NPSs, namely a hydrogen bonding towards the NH group, was confirmed using DFT calculations and NMR titration. Importantly, the calix[4]arene derivative as the receptor of the potentiometric sensor provides (1) discrimination between cathinone derivatives themselves and cathinones from aminoindane as well as the (2) possibility of detection of buphedrone in samples containing the mixture of the different NPSs including cathinones (Sr ≤ 0.11). Conclusions: A potentiometric sensor based on calix[4]arene derivative provided a rapid and perspective technique for the detection of cathinone derivatives. These results show that potentiometric sensors can become promising future tools for NPSs detection. © 2019, Japanese Association of Forensic Toxicology.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/VI20172020056" target="_blank" >VI20172020056: New synthetics drugs - complex interdisciplinary research centre</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Forensic Toxicology
ISSN
1860-8965
e-ISSN
—
Volume of the periodical
38
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
"70 "- 78
UT code for WoS article
000512985000006
EID of the result in the Scopus database
2-s2.0-85068349375