Functionalized Germanene-Based Nanomaterials for the Detection of Single Nucleotide Polymorphism

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43922150" target="_blank" >RIV/60461373:22310/21:43922150 - isvavai.cz</a>

Result on the web

<a href="https://pubs.acs.org/doi/full/10.1021/acsanm.1c00606" target="_blank" >https://pubs.acs.org/doi/full/10.1021/acsanm.1c00606</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsanm.1c00606" target="_blank" >10.1021/acsanm.1c00606</a>

Result language

angličtina

Original language name

Functionalized Germanene-Based Nanomaterials for the Detection of Single Nucleotide Polymorphism

Original language description

2D monoelemental materials beyond graphene, such as germanene, have recently garnered extensive attention due to their tunable optical and electronic properties. While the performance of germanene-based materials, for example, germanane, for energy storage and catalysis applications has been previously examined, to the best of our knowledge their use for electrochemical biosensing has yet to be widely explored. To this aim, a disposable genosensor, with three different types of nanosized germananes, namely, germanane, methylgermanane, and cyanopropylgermanane, is proposed here for the sensitive and selective detection of Alzheimer-related single nucleotide polymorphism (SNP) using electrochemical impedance spectroscopy. Among the three materials, germanane enabled excellent bioanalytical performance and showcased rapid electron transfer rates for the detection of SNP, providing a linear range between 1 × 10-12 and 1 × 10-8 M and with a detection limit of 34 pM under optimized conditions. Moreover, the potential of the developed device for miniaturization and decentralized analysis is demonstrated with the use of a disposable electrode printed chip (DEP-chip). This study not only demonstrated the potential use of germanene-based nanomaterials as a biosensing platform but also provided a platform to tailor their chemical features to achieve the optimal biosensing performance. © 2021 American Chemical Society.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10402 - Inorganic and nuclear chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Applied Nano Materials

ISSN

2574-0970

e-ISSN

—

Volume of the periodical

4

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

5164-5175

UT code for WoS article

000657373800090

EID of the result in the Scopus database

2-s2.0-85108360387