Exosomes produced by melanoma cells signifcantly infuence the biological properties of normal and cancer‐associated fbroblasts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F21%3A43923433" target="_blank" >RIV/60461373:22310/21:43923433 - isvavai.cz</a>

Result on the web

<a href="https://link.springer.com/article/10.1007/s00418-021-02052-2" target="_blank" >https://link.springer.com/article/10.1007/s00418-021-02052-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00418-021-02052-2" target="_blank" >10.1007/s00418-021-02052-2</a>

Result language

angličtina

Original language name

Exosomes produced by melanoma cells signifcantly infuence the biological properties of normal and cancer‐associated fbroblasts

Original language description

The incidence of cutaneous malignant melanoma is increasing worldwide. While the treatment of initial stages of the disease is simple, the advanced disease frequently remains fatal despite novel therapeutic options . This requires identification of novel therapeutic targets in melanoma. Similarly to other types of tumours, the cancer microenvironment plays a prominent role and determines the biological properties of melanoma. Importantly, melanoma cell-produced exosomes represent an important tool of intercellular communication within this cancer ecosystem. We have focused on potential differences in the activity of exosomes produced by melanoma cells towards melanoma-associated fibroblasts and normal dermal fibroblasts. Cancer-associated fibroblasts were activated by the melanoma cell-produced exosomes significantly more than their normal counterparts, as assessed by increased transcription of genes for inflammation-supporting cytokines and chemokines, namely IL-6 or IL-8. We have observed that the response is dependent on the duration of the stimulus via exosomes and also on the quantity of exosomes. Our study demonstrates that melanoma-produced exosomes significantly stimulate the tumour-promoting proinflammatory activity of cancer-associated fibroblasts. This may represent a potential new target of oncologic therapy .

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Histochemistry and Cell Biology

ISSN

0948-6143

e-ISSN

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Volume of the periodical

157

Issue of the periodical within the volume

2

Country of publishing house

CH - SWITZERLAND

Number of pages

20

Pages from-to

153-172

UT code for WoS article

000722977300001

EID of the result in the Scopus database

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